Technically, Asimov’s Guide to Shakepeare and Asimov’s Guide to the Bible are not annotations in the sense that the entire work is included and commented on. But Asimov wrote that he thought it wasn’t practical to include the entire work because both the Bible and the works of Shakespeare are far too long.
The one I find people forget about the most is Familiar Poems, Annotated, which is itself a fascinating read. I sometimes wish I’d read it before taking AP English in 12th grade. I might have argued with the teacher’s interpretations more.
The only one that I am missing is, naturally, the one I want the most and that is Asimov’s Annotated Paradise Lost.
Anyway, there they are, prime examples that Asimov wrote more than just science and science fiction. And the four actual annotations pictured above are all first editions. (Guide to the Bible and Guide to Shakespeare are not.)